10. TV: Red Band Society
The premise of Red Band Society, which centers on an unlikely group of very different young people thrown together, calls to mind a show like Glee. But rather than a high school, the new Fox series takes place at a hospital. From eating disorders to comas to cancer, the teens strive to cope with health problems in addition to the normal teenage drama of cliques, bullying, and new love. Throw in sassy nurses played by Octavia Spencer and GLAAD's Wilson Cruz as well as a hot doctor portrayed by Dave Annable (Brothers & Sisters) and we have just have a hit on our hands. Red Band Society premieres Wednesday. Watch the trailer below. -- Daniel Reynolds

9. MUSIC: "Trouble in Paradise," Isabel Rose
Songstress Isabel Rose serves up the sounds of classic 1960s Vegas with a modern twist in her new music video. "Trouble in Paradise." The sultry song is the latest single from Rose's upcoming album of the same name (to be released Tuesday), which includes a remix of "Reflections" created by the legendary Frankie Knuckles -- their final collaboration before Knuckles died. This tasty production is made even sweeter with guest appearances by drag divas Hedda Lettuce, Paige Turner, and Ivy Winters, who perfectly complement Rose's classy voice with an infusion of campy sass. Get into "Trouble in Paradise" below and watch Rose stir up some mischief live onstage at the Cutting Room in New York Tuesday. -- Jase Peeples

8. THEATER: Methtacular!
If you've ever wanted to know what it's like to be addicted to crystal meth for a couple of years, then out writer-actor Steven Strafford is your man. In his show Methtacular!Stafford relates his autobiographical account of his addiction both hilariously and heartbreakingly. This Sunday after the 4 p.m. performance, stick around to talk recovery with Strafford and a panel of experts. Wednesdays through Saturdays, 7:30 p.m., Sundays 4 p.m., through September 28, Theater Wit, Chicago. -- Michelle Garcia

7. ART: Queer Art Expo
Check out queer, erotic, kink, and fetish artworks, plus enjoy drinks, music by DJ Daddy Deluxx, and giveaways at the Queer Art Expo Saturday from noon to 6 p.m. at Rough Trade Gear in Los Angeles. Among the many featured artists are Boots Bryant, Harvey Del Rey, Hector Silva, Brandon Michael Spear, and Andrew Cervantes, and proceeds benefit the Tom of Finland Foundation. -- Trudy Ring

6. TV: The Roosevelts: An Intimate History
A Ken Burns documentary is always a major event, and for this fall's entry Burns turns his attention to Theodore, Franklin, and Eleanor Roosevelt in a seven-part, 14-hour series. Word is that Burns and collaborator Geoffrey Ward don't believe Eleanor had a love affair with lesbian journalist Lorena Hickok, but they do feature historians who beg to differ -- despite Burns's unfortunate recent reference to the subject as "tabloid history." The series begins Sunday on most PBS stations, but check your local listings; it also will be available online starting Monday. Watch a preview below. -- Trudy Ring

5. COMICS: The Whedon Three Way
The adventures of fan favorite characters from Joss Whedon's classic TV shows Buffy the Vampire Slayer, Angel, and Serenity continue in the pages of Dark Horse Comics. The Whedon Three Way is a perfect jumping-on point for new readers. The value-packed issue offers three number ones of the newest Whedon series: Buffy the Vampire Slayer season 10, Angel & Faith season 10, and Serenity: Leaves on the Wind for only $1. Available now. -- Jase Peeples

4. WEB: "Cell Black Django" by Todrick Hall
Todrick Hall's parody videos are Internet entertainment gold, and his latest creation is no exception. "Cell Black Django" replaces the famed ladies of Chicago's "Cellblock Tango" with look-alikes of pop stars Nicki Minaj, Rihanna, Solange, Beyonce, and Mariah Carey. The video brilliantly spoofs the real-life drama these divas have faced down throughout their careers and weaves it into the a tale of "the six ratchet murderesses of Crenshaw County Jail." -- Jase Peeples

3. EVENT: Uprising of Love: Benefit Concert for Global Equality
Be entertained and raise funds for the global LGBTI equality fight? Sounds like a good way to spend a Monday night. The latest edition of this annual event will feature Sting, Patti LuPone, and Jane Lynch, and the net proceeds will go to Fueling the Front Lines, which is the Astraea Lesbian Foundation for Justice's $20 million campaign to lobby for equal rights around the world. Monday, 8 p.m., Gershwin Theatre, New York City. -- Michelle Garcia

2. FILM: The Skeleton Twins
Kristin Wiig and Bill Hader star in The Skeleton Twins, a dark comedy about the relationship between a woman and her gay twin. After years apart, Milo (Hader) returns to live with his estranged sister, Maggie (Wiig), after breaking up with his boyfriend. He is disturbed to find his sibling leading a seemingly perfect life of domestic bliss with her Pollyanna fiance (Luke Wilson). Things are not as they seem, however, and Milo gets under Polly's skin to reveal the tensions brewing just beneath. Directed by Craig Johnson, who recently wrote an op-ed for The Advocate titled "What Makes a Film 'Gay'?," The Skeleton Twins garnered the Waldo Salt Screenwriting Award at Sundance for its heartwarming and heartbreaking comedy about the relationship between two siblings on the brink. It opens Friday. Watch the trailer below. -- Daniel Reynolds

1. MUSIC: Partners, Barbra Streisand
Entertainment icon Barbra Streisand has teamed up with 12 legendary male vocalists for her latest album, Partners. The LP, which will be released Tuesday, offers a dozen songs, many of which are regarded as Streisand classics, which have been reworked as duets. Among the songs included are "New York State of Mind" with Billy Joel, "It Had to Be You" with Michael Buble, "Come Rain or Come Shine" with John Mayer, "Love Me Tender" with Elvis Presley, "The Way We Were" with Lionel Richie, "What Kind of Fool" with John Legend, "People" with Stevie Wonder, "I Can Still See Your Face" with Andrea Bocelli, "Evergreen" with Babyface, and her first studio-recorded duet with her son, Jason Gould, on "How Deep Is the Ocean." Soak up a sneak peek of Streisand's collaboration with her son below, and for the latest on iconic artist, visit BarbraStreisand.com -- Jase Peeples