John Griffiths

If the Hollywood buzz is sawing right, Katherine Heigl is about to slice off a chunk of movie stardom. This month she's starring in the new Judd Apatow (The 40-Year-Old Virgin) comedy, Knocked Up. But the Connecticut-bred charmer cut her way into our hearts as Izzie Stevens, the earnest intern on ABC's smash hit Grey's Anatomy, and earned her BGF overnight by famously taking a Grey's costar to task for some homophobic comments. Here the outspoken actress talks about her BFF (our cover boy, T.R. Knight, of course!), her frustration with the f word, and her yen to have a gay kid--just not for a while.

Julian McMahon has no sexual hang-ups, and he's not afraid to say so.